Where CVD happens
Damaged venous valves - Pathogenesis
The peripheral venous system is naturally at an overall low pressure. Venous valves can weaken for a variety of reasons such as a late consequence of deep vein thrombosis, hormonal changes during pregnancy, or a sedentary lifestyle. When venous valves weaken or there are abnormalities in the venous walls, blood can flow backward and increases the pressure in the peripheral venous system, known as venous hypertension. If venous hypertension is sustained over time the vein walls stretch and the valve cusps no longer meet when the valves close. This further increases the hypertension, which can lead to swelling, discomfort and varicose veins. If the increased blood pressure and symptoms are not addressed, chronic venous insufficiency can develop.